What is the Cause of Pancreatic Cancer and How is it Detected?

No one can catch cancer from another person.A special x-ray of the blood vessels (angiogram).
While it can seldom be explained why one personX-rays (CT scans), pictures that are created by a
gets any type of cancer and another doesn't, it iscomputer, that give detailed cross-section images
very clear that the disease is not contagious.of the pancreas.
Although research scientists do not know theTransabdominal ultrasound. This type of ultrasound
exact causes of cancer of the pancreas, they areprocedure uses an instrument that sends out
always learning some things that can increase ahigh-frequency sound waves and is passed over
person's chance of getting this disease. Smokingthe abdomen. The sound waves form a picture
of any kind is a major risk factor and researchon a screen as they echo off the pancreas.
shows that cigarette smokers tend to developEndoscopic retrograde cholangiopancreatogram
cancer of the pancreas two to three times more(ERCP), is a special x-ray procedure of the
often than nonsmokers. So by quitting smoking,common bile duct. For this test, the patient is
you will reduce the risk of pancreatic cancer, lunggiven some type of sedation as a long, flexible
cancer, as well as a number of other diseases.tube (endoscope) is passed down the patient's
What are the specific symptoms of pancreaticthroat, through the stomach and into the small
cancer?intestine. A dye is then injected into the common
Pancreatic cancer has been referred to as a silentbile duct, and x-rays are taken. The endoscope
killer mainly because the early stages ofalso allows the doctor to obtain tissue samples.
pancreatic cancer usually do not cause anyAnother relatively new procedure, Endoscopic
symptoms. If a tumor happens to block theultrasound can be used to diagnose pancreatic
common bile duct and prevents the bile fromcancer. For this procedure, an endoscope is
passing into the digestive system, both the skinpassed in the same way as for ERCP; however,
and whites of the eyes may become jaundicedat the end of the endoscope is an ultrasound
(yellow), and the urine may change color andprobe, which can scan the pancreas for tumors.
become darker.Because the ultrasound probe can be closer to
As the tumor continues to grow and spread, painthe pancreas than with transabdominal ultrasound,
usually develops in the area of the upperit is very possible that the doctor can identify
abdomen and can sometimes spread to the back.small cancers that are within the pancreas. Tissue
The pain can become worse after the personsamples can also be obtained through the
eats food or lies down. Cancer of the pancreasendoscope.
can also cause other symptoms, such as: nausea,A biopsy is the only definite way for the doctor
loss of appetite, weight loss, and weakness.to determine if cancer is present. In the biopsy,
Islet cell cancer (islets of Langerhans) is a rarethe doctor will remove a piece of tissue from the
type of pancreatic cancer. It begins in the cells ofpancreas. A pathologist then examines the tissue
the pancreas that produce the body's insulin andsample under a microscope to check for cancer
other hormones.cells.
The islet cell cancer may cause the pancreas toTissue samples that are obtained with one kind of
produce an abundance of insulin or otherbiopsy may not give a clear diagnosis, and the
hormones and if this happens, the patient maybiopsy may need to be repeated using a different
experience a feeling of being weak or dizzy, havemethod.
chills, muscle spasms, or diarrhea. TheseOne of the ways to obtain tissue is by using a
symptoms can be caused by cancer itself orlong needle that is passed through the skin and
from other, less serious problems. If an individualinto the pancreas, hence the name needle biopsy.
experiences the symptoms, a doctor should beDoctors will use either x-rays or ultrasound to
consulted as soon as possible.properly guide the placement of the needle to
How is pancreatic cancer diagnosed?obtain the sample.
The accurate diagnosis of pancreatic cancerA brush biopsy is performed during the ERCP.
requires that the doctor does a complete physicalThe doctor will insert a very small brush through
exam, including lab tests and asks about thethe endoscope into the bile duct and rub off cells
patient's personal and family medical history. Into examine under a microscope. Sometimes,
addition to checking the patient's general signswhen a biopsy does not provide an accurate
(temperature, pulse, blood pressure), the doctorindication, a surgeon will perform an operation
will usually order a complete blood profile, urine,called a laparotomy. During this operation, the
and stool tests. The doctor may also ask for andoctor will look at the organs in the abdomen and
upper GI series. For the upper GI (gastrointestinal)can remove tissue samples, if needed from any
test, the patient is required to drink a bariumorgan. This surgical procedure helps the doctor
solution before any x-rays of the upper digestivedetermine the stage or extent of the disease.
system are taken. The barium will show an outlineThis will help the doctor plan the best approach
of the pancreas on the x-rays.for treatment.
The doctor may order other tests such as: