| <!-- @page { size: 21cm 29.7cm; margin: 2cm } | | | | melanocyte survival. |
| P { margin-bottom: 0.21cm } --> | | | | It is often difficult to design drugs that interfere |
| Although melanoma is not a new disease, | | | | with transcription factors, but perhaps new drugs |
| evidence for its occurrence in antiquity is rather | | | | will be discovered that can impede some reaction |
| scarce. However, one example lies in a 1960s | | | | in the pathway upstream of MITF. Studies of |
| examination of nine Peruvian Inca mummies, | | | | chromatin structure also promise to shed light on |
| radiocarbon dated to be approximately 2400 | | | | transcriptional regulation in melanoma cells. It has |
| years old, which showed apparent signs of | | | | long been assumed that nucleosomes are |
| melanoma: melanotic masses in the skin and | | | | positioned randomly on DNA. |
| diffuse metastases to the bones. | | | | But murine studies of genes involved in melanin |
| John Hunter is reported to be the first to operate | | | | production now suggest that nucleosomes are |
| on metastatic melanoma in 1787. Although not | | | | stereotypically positioned on DNA. When a gene is |
| knowing precisely what it was, he described it as | | | | undergoing transcription, its transcription start site |
| a "cancerous fungous excrescence". The excised | | | | is almost always nucleosome-free. When the gene |
| tumor was preserved in the Hunterian Museum of | | | | is silent, however, nucleosomes often block the |
| the Royal College of Surgeons of England. It was | | | | transcriptional start site, suggesting that |
| not until 1968 that microscopic examination of the | | | | nucleosome position may play a role in gene |
| specimen revealed it to be an example of | | | | regulation. |
| metastatic melanoma. | | | | Given the fact that melanin helps protect skin cells |
| The French physician René Laennec was the | | | | from UV-induced damage, new melanoma |
| first to describe melanoma as a disease entity. His | | | | prevention strategies could involve attempts to |
| report was initially presented during a lecture for | | | | induce melanin synthesis in individuals who would |
| the Faculté de Médecine de Paris in 1804 and | | | | otherwise get sunburns. Redheads, for example, |
| then published as a bulletin in 1806. The first | | | | do not tan because they have MC1R mutations. |
| English language report of melanoma was | | | | Perhaps such a strategy will eventually be used to |
| presented by an English general practitioner from | | | | protect humans from melanoma. |
| Stourbridge, William Norris in 1820. | | | | NeviCurative is a powerful all natural topical |
| In his later work in 1857 he remarked that there | | | | treatment proven to eliminate and defeat moles |
| is a familial predisposition for development of | | | | or nevi. The pharmacological strength of |
| melanoma. The first formal acknowledgment of | | | | NeviCurative provides effective elimination of |
| advanced melanoma as untreatable came from | | | | moles without scarring, tissue damage, or |
| Samuel Cooper in 1840. He stated that the only | | | | recurrence. The treatment is painless and delivers |
| chance for benefit depends upon the early | | | | profound results in the elimination of moles, |
| removal of the disease. More than one and a half | | | | returning skin tissue back to its original state. |
| centuries later this situation remains largely | | | | Recent clinical trials have established the ability of |
| unchanged. | | | | the active constituents in NeviCurative to |
| One important pathway in melanin synthesis | | | | effectively eradicate skin moles and impair the |
| involves the transcription factor MITF. The MITF | | | | growth of human melanoma cells. NeviCurative |
| gene is highly conserved and is found in people, | | | | has therefore been shown to eliminate even the |
| mice, birds, and even fish. MITF production is | | | | most stubborn moles, regardless of their location |
| regulated via a fairly straightforward pathway. UV | | | | on the body, even when other treatments have |
| radiation causes increased expression of | | | | failed. |
| transcription factor p53 in keratinocytes. | | | | NeviCurative is well-known for its antioxidant |
| P53 causes these cells to produce melanocyte | | | | properties. It is comprised of certified organic |
| stimulating hormone, which binds to melanocortin 1 | | | | medicinal plant extracts, which have demonstrated |
| receptors (MC1R) on melanocytes. Ligand-binding | | | | their ability to eradicate melanomas and skin |
| at MC1R receptors activates adenylate cyclases, | | | | tumors in laboratory tests. These extracts have a |
| which produce cAMP, which activates CREB, which | | | | remarkable array of pharmacological and |
| promote MITF expression. The targets of MITF | | | | biochemical properties, which are highly effective |
| include p16 and Bcl2, a gene essential to | | | | in eradicating moles. |