| As the results of the first phase of trials published | | | | reduction level for 18 months. |
| in the Journal of Clinical Oncology, abiraterone | | | | Side effects were generally mild, but it reminds |
| gained instant critical as the miracle drug to treat | | | | patients under hormone replacement therapy. |
| prostate cancer. The mainstream media | | | | These include a change in the levels of sodium |
| immediately pounced on the story during the | | | | and potassium in the blood, an accumulation of |
| middle of July 2008 from the drug as the most | | | | fluid in the ankles / edema Overall, an increase in |
| significant advance in the field of therapy of | | | | blood pressure, headaches, loss of appetite, |
| prostate cancer in 70 years. Despite the promising | | | | fatigue and hot flushes. |
| results during its first test abiraterone could | | | | Phase 2 trials are underway but results have not |
| legitimately have earned their bragging rights. | | | | yet been published. Focused on men whose |
| Given that history of prostate cancer, research | | | | previous hormone therapy no longer works. |
| shows that around the world, almost one third of | | | | These men were abiraterone that the abiraterone |
| men diagnosed with the disease die from it. | | | | no longer worked, they were then given a steroid |
| Prostate cancer usually affects men who have | | | | called dexamethasone. The first results were |
| arrived in the fifties, and the risk increases the | | | | announced in June 2008, and it looked promising, |
| older they get. To detect or examine suspected | | | | were hailed by the media as the biggest |
| cases of prostate cancer, the doctor usually | | | | breakthrough in research on prostate cancer. Men |
| begins with a prostate specific antigen or PSA | | | | who were taking only abiraterone ï ¿½ "the |
| bloodwork then a biopsy if a review shows | | | | majority of them ï ¿½" show a drop in their |
| positive indicators for the disease. At present, | | | | PSA levels. A sure sign of the treatment stopped |
| only early detection ensures recovery of most | | | | the cancer from growing or developing. In 50% of |
| cases of prostate cancer. | | | | men with tumors can be measured in the scan, |
| The male hormone testosterone ï ¿½ | | | | the cancer is reduced or didnâ € ™ t grow |
| "even though it performs a vital function in the | | | | even more. PSA levels were reduced by half in |
| male anatomy ï ¿½" stimulates prostate | | | | almost 70% of men participating in clinical trials |
| cancer tumors to grow. Current therapies used to | | | | despite the fact that the PSA level of men |
| treat prostate cancer usually involves stopping the | | | | involved has increased again after 7 months. |
| body from making testosterone. This method can | | | | Despite the promising results, abiraterone is |
| slow the growth of existing tumors, or even | | | | currently only available for men who take part in |
| shrink. The majority of testosterone in the male | | | | a clinical trial. |
| anatomy is made by the testes, but a significant | | | | Based on provisional results, the last abiraterone |
| ï ¿½ "ï ¿albeit small ½" is synthesized | | | | trial participants should be examined as a |
| in other tissues in the body, including cancer itself. | | | | precaution. Because the drug changes the levels |
| To create or synthesize testosterone, the body | | | | of sodium and potassium in the blood and |
| needs an enzyme called cytochrome P17, often | | | | increases blood pressure, men with a history of |
| called in the CYP17 research € ™ s â € | | | | heart disease and high blood pressure are not |
| œWhite Paper €?. | | | | allowed to participate in trials abiraterone. So the |
| Abiraterone, whose chemical name is abiraterone | | | | men who have undergone treatment with a drug |
| acetate, also known as CB7630 works differently | | | | called ketoconazole, has a history of liver disease |
| compared to other hormonal treatments for | | | | or currently have another type of cancer and / |
| prostate cancer. Abiraterone acetate has a broad | | | | or secondary cancer in the brain. Experts say that |
| spectrum in blocking the enzyme CYP17, thus | | | | based on all hormone therapy to cure prostate |
| preventing the testes and other tissues in the | | | | cancer ï ¿½ "ï ¿½ including |
| body of the synthesis of testosterone. | | | | abiraterone" carries the risk of impotence, urinary |
| Abiraterone has been recently used in clinical trials | | | | tract problems and incontinence. |
| as an experimental treatment for prostate | | | | In the past, prostate cancer tends to be the |
| cancer. These first clinical trials focused on men | | | | forefront of consciousness when someone |
| with advanced prostate cancer whose prior | | | | famous only helped overcome the disease by |
| treatment no longer works as well for men with | | | | current treatment regimen at the time. In |
| advanced prostate cancer that has spread or | | | | November 1987, USA President Ronald Reagan |
| metastasis beyond the prostate gland. | | | | underwent surgery transurethral prostate due to |
| Results of the Phase 1 trial were recently | | | | benign prostatic hypertropy, causing a heightened |
| published in the Journal of Clinical Oncology. | | | | awareness of prostate cancer. In the world of |
| Abiraterone during the trials, 80% of men had a | | | | entertainment, Bill Foxa € œThe â €? |
| decrease in their levels of prostate specific | | | | Foster Emcee Comedy Centrala € ™ s â |
| antigen (PSA) in blood accompanied by tumor | | | | € œThe man Showa €? died of prostate |
| shrinkage. A fall in PSA levels usually the number | | | | cancer in May 10, 2000. His family asked that we |
| of cancer cells has been reduced. Some of the | | | | (The Man Show fans) to honor his memory by |
| men who suffer from chronic pain from his | | | | urging viewers to get their male prostates |
| prostate cancer tumors were able to take much | | | | examined regularly by your doctor. Many felt that |
| lower doses of painkillers, a sure sign of | | | | with early detection, the bill â € œThe Foxa |
| improvement. PSA reduction lasted just over two | | | | €? Fostered € ™ s death could have |
| months in some men, while on other issues, the | | | | been avoided. |